Huntington disease

Common Name(s)

Huntington disease, Huntington's chorea

Huntington disease is a progressive disorder that causes brain cell (neuron) degeneration in certain areas of the brain.  This results in uncontrolled movements, loss of intellectual abilities, and emotional disturbances. Symptoms typically appear between the ages of 35 and 44 years. People with Huntington disease most often live for 15 to 18 years after the condition appears. Huntington disease caused by mutations in the HTT gene and is inherited in an autosomal dominant manner. Each child of a person with Huntington disease has a 50 percent (1 in 2) chance of inheriting the mutation. There is also a less common, early-onset from that begins in childhood or adolescence, called juvenile Huntington disease.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Huntington disease" for support, advocacy or research.

Caring Voice Coalition,Inc,

Caring Voice Coalition empowers patients who live with a life threatening chronic disease through comprehensive outreach programs and services aimed at financial, emotional and educational support. With a steadfast dedication to the organization’s set of core values, our knowledgeable, caring staff maintains our solid reputation as a dependable, responsive organization with a unique, holistic approach to improving the lives of our patients.

Last Updated: 17 Feb 2017

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Hereditary Disease Foundation

The Hereditary Disease Foundation is a non-profit, basic-science organization dedicated to the cure of genetic disease, with a focus on Huntington disease.

Last Updated: 1 Mar 2013

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Huntington's Disease Society of America

We are a national non-profit voluntary health agency dedicated to finding a cure for Huntington's Disease. We provide vital support, information and educational services to improve the lives of those affected by HD, offer resources and guidance for HD families through our national network of volunteer-based chapters and affiliates as well as through our HDSA Centers of Excellence for Family Services, and promote and support research to find a cure for HD.

Last Updated: 11 Oct 2012

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Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

Last Updated: 5 May 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Huntington disease" for support, advocacy or research.

Caring Voice Coalition,Inc,

Caring Voice Coalition empowers patients who live with a life threatening chronic disease through comprehensive outreach programs and services aimed at financial, emotional and educational support. With a steadfast dedication to the organization’s set of core values, our knowledgeable, caring staff maintains our solid reputation as a dependable, responsive organization with a unique, holistic approach to improving the lives of our patients.

http://www.caringvoice.org

Last Updated: 17 Feb 2017

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Hereditary Disease Foundation

The Hereditary Disease Foundation is a non-profit, basic-science organization dedicated to the cure of genetic disease, with a focus on Huntington disease.

http://www.hdfoundation.org

Last Updated: 1 Mar 2013

View Details
Huntington's Disease Society of America

We are a national non-profit voluntary health agency dedicated to finding a cure for Huntington's Disease. We provide vital support, information and educational services to improve the lives of those affected by HD, offer resources and guidance for HD families through our national network of volunteer-based chapters and affiliates as well as through our HDSA Centers of Excellence for Family Services, and promote and support research to find a cure for HD.

http://www.hdsa.org

Last Updated: 11 Oct 2012

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Movement Disorder Society

The Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals, who are interested in Parkinson's disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic movement disorders, and abnormalities in muscle tone and motor control.

http://www.movementdisorders.org/MDS.htm

Last Updated: 5 May 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Huntington disease" returned 398 free, full-text research articles on human participants. First 3 results:

Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition.
 

Author(s): Florian A Siebzehnrübl, Kerstin A Raber, Yvonne K Urbach, Anja Schulze-Krebs, Fabio Canneva, Sandra Moceri, Johanna Habermeyer, Dalila Achoui, Bhavana Gupta, Dennis A Steindler, Michael Stephan, Huu Phuc Nguyen, Michael Bonin, Olaf Riess, Andreas Bauer, Ludwig Aigner, Sebastien Couillard-Despres, Martin Arce Paucar, Per Svenningsson, Alexander Osmand, Alexander Andreew, Claus Zabel, Andreas Weiss, Rainer Kuhn, Saliha Moussaoui, Ines Blockx, Annemie Van der Linden, Rachel Y Cheong, Laurent Roybon, Åsa Petersén, Stephan von Hörsten

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2018 09;115(37):E8765-E8774.

 

Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by expanded CAG repeats in the gene (). Although mutant HTT is expressed during embryonic development and throughout life, clinical HD usually manifests later in adulthood. A number of studies document ...

Last Updated: 31 Dec 1969

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Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease.
 

Author(s): Dagmar E Ehrnhoefer, Dale D O Martin, Mandi E Schmidt, Xiaofan Qiu, Safia Ladha, Nicholas S Caron, Niels H Skotte, Yen T N Nguyen, Kuljeet Vaid, Amber L Southwell, Sabine Engemann, Sonia Franciosi, Michael R Hayden

Journal:

 

Huntington disease (HD) is caused by the expression of mutant huntingtin (mHTT) bearing a polyglutamine expansion. In HD, mHTT accumulation is accompanied by a dysfunction in basal autophagy, which manifests as specific defects in cargo loading during selective autophagy. Here we ...

Last Updated: 31 Dec 1969

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Alteration in Fluidity of Cell Plasma Membrane in Huntington Disease Revealed by Spectral Phasor Analysis.
 

Author(s): Sara Sameni, Leonel Malacrida, Zhiqun Tan, Michelle A Digman

Journal:

 

Huntington disease (HD) is a late-onset genetic neurodegenerative disorder caused by expansion of cytosine-adenine-guanine (CAG) trinucleotide in the exon 1 of the gene encoding the polyglutamine (polyQ). It has been shown that protein degradation and lipid metabolism is altered in ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Huntington disease" returned 33 free, full-text review articles on human participants. First 3 results:

Evaluating the current state of the art of Huntington disease research: a scientometric analysis.
 

Author(s): L A Barboza, N C Ghisi

Journal:

 

Huntington disease (HD) is an incurable neurodegenerative disorder caused by a dominant mutation on the 4th chromosome. We aim to present a scientometric analysis of the extant scientific undertakings devoted to better understanding HD. Therefore, a quantitative study was performed ...

Last Updated: 31 Dec 1969

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Preimplantation genetics and other reproductive options in Huntington disease.
 

Author(s): Jan K Blancato, Erin M Wolfe, Preston C Sacks

Journal: Handb Clin Neurol. 2017 ;144():107-111.

 

Preimplantation genetic diagnosis (PGD) is a form of prenatal diagnosis applied to potential parents with known carrier status of a genetic disease, such as Huntington disease. It employs the use of polymerase chain reaction to amplify single cells from early embryos obtained with ...

Last Updated: 31 Dec 1969

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Development of Research on Huntington Disease in China.
 

Author(s): Hong-Lei Li, Yan-Bin Zhang, Zhi-Ying Wu

Journal: Neurosci Bull. 2017 Jun;33(3):312-316.

 

Huntington disease (HD) is a progressive autosomal dominantly inherited neurodegenerative disorder, characterized with the typical manifestations of involuntary movements, cognitive dysfunction, and psychiatric or behavioral disturbance. It results from an expansion in the number ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Huntington's Disease 123
 

Status: Not yet recruiting

Condition Summary: Huntington Disease

 

Last Updated: 14 Sep 2018

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Dose-response Evaluation of the Cellavita HD Product in Patients With Huntington's Disease
 

Status: Recruiting

Condition Summary: Huntington Disease

 

Last Updated: 17 Sep 2018

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Deep Brain Stimulation (DBS) of the Globus Pallidus (GP) in Huntington's Disease (HD)
 

Status: Recruiting

Condition Summary: Huntington Disease

 

Last Updated: 26 Jul 2018

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