Keratoacanthoma

Common Name(s)

Keratoacanthoma, Muir-Torre Syndrome

Muir-Torre syndrome is an autosomal dominant skin condition of genetic origin, characterized by tumors of the sebaceous gland or keratoacanthoma that are associated with visceral malignant diseases (cancers of the internal organs). The cutaneous characteristics of Muir-Torre syndrome are sebaceous adenoma, sebaceous epithelioma, sebaceous carcinoma, or multiple keratoacanthomas, whereas visceral malignant diseases include colorectal, endometrial, urological, and upper gastrointestinal tumors. Men are affected twice as often as women. Muir-Torre syndrome is associated with hereditary non-polyposis colon cancer (HNPCC), an autosomal dominant cancer genetic syndrome. Sebaceous neoplasms associated with Muir-Torre syndrome exhibit microsatellite instability (MSI), as do other HNPCC-related cancers.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Keratoacanthoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Keratoacanthoma" returned 71 free, full-text research articles on human participants. First 3 results:

[Keratoacanthoma of the left forearm].
 

Author(s): Youssef Zemmez, Naoufal Hjira

Journal:

 

We here report the case of a 54-year old woman presenting with a swelling in the left forearm occurred eight weeks before and rapidly increasing in volume. Clinical examination showed ulcero-budding painless purplish skin lesion measuring 2 cm along its longer axis (A). The patient ...

Last Updated: 31 Dec 1969

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Keratoacanthoma centrifugum marginatum: an unusual clinical and histopathological diagnostic pitfall.
 

Author(s): Tiberiu Augustin Georgescu, Ana Maria Oproiu, Mihai George Rădăşan, Adrian Vasile Dumitru, Diana Costache, Oana Maria Pătraşcu, Anca Mihaela Lăzăroiu, Alina Elena Chefani, Maria Sajin, Mariana Costache

Journal: Rom J Morphol Embryol. 2017 ;58(2):561-565.

 

Keratoacanthoma centrifugum marginatum (KCM) is a very rare variant of keratoacanthoma characterized by progressive peripheral growth accompanied by central healing. The tumor has the peculiar ability to involute spontaneously. A careful differential diagnostic with other skin carcinomas ...

Last Updated: 31 Dec 1969

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Aberrant DNA Methylation in Keratoacanthoma.
 

Author(s): Yoshimasa Nobeyama, Hidemi Nakagawa

Journal:

 

Keratoacanthoma (KA) is a self-limiting epidermal tumor for which histopathological examination sometimes suggests malignancy. Based on inconsistent clinical views, KA can be regarded as both a benign tumor and a variant of squamous cell carcinoma (SCC). Aberrant DNA methylation frequently ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Keratoacanthoma" returned 5 free, full-text review articles on human participants. First 3 results:

Keratoacanthoma of the conjunctiva - case report and review of the literature.
 

Author(s): Bianca Aurora Szabo, Alina Simona Şovrea, Dana Monica Bartoş, Adrian Bartoş, Carmen Georgiu

Journal: Rom J Morphol Embryol. 2017 ;58(4):1605-1609.

 

Keratoacanthoma (KA) is a relatively common, benign, rapidly growing and self-limiting squamous proliferation, which appears most frequently on the sun-exposed skin. The nature of KA and its relationship to squamous cell carcinoma (SCC) still represent one of the major debates in ...

Last Updated: 31 Dec 1969

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[Role of the pathologist in the diagnosis of palpebral keratoacanthoma: case report and literature review].
 

Author(s): A Harmouch, M C Chefchaouni, M Maher, S Sefiani

Journal: J Fr Ophtalmol. 2012 Dec;35(10):816.e1-3.

 

We report the case of a keratoacanthoma of the lower lid in a 14-year-old girl posing diagnostic difficulty with differentiating the lesion from a verrucous squamous cell carcinoma on histologic examination of an incisional biopsy. It was only upon complete excision of the tumor that ...

Last Updated: 31 Dec 1969

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Keratoacanthoma of the inferior lip: review and report of case with spontaneous regression.
 

Author(s): Lara Maria A Ramos, Sérgio V Cardoso, Adriano M Loyola, Marcus A Rocha, Antônio Francisco Durighetto-Júnior

Journal: J Appl Oral Sci. ;17(3):262-5.

 

Keratoacanthoma (KA) is a self-limited benign epithelial proliferative lesion that eventually presents with very similar clinical features to squamous cell carcinoma. Many KA appear in the vermilion border of the lips and therefore dental professionals must be familiar of the disease. ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of TVEC in Patients With Cutaneous Squamous Cell Cancer
 

Status: Recruiting

Condition Summary: Squamous Cell Carcinoma; Skin Cancer; Keratoacanthoma; Cutaneous Tumor; Skin Cancer, Squamous Cell; Lesion Skin

 

Last Updated: 19 Oct 2018

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Pain Outcomes Following Intralesional Corticosteroid Injections
 

Status: Not yet recruiting

Condition Summary: Keloid; Alopecia Areata; Acne; Hypertrophic Scar; Epidermal Inclusion Cyst; Frontal Fibrosing Alopecia; Lichen Plano-Pilaris; Keratoacanthoma; Plaque Psoriasis; Lichen Simplex Chronicus; Prurigo Nodularis; Nummular Eczema; Granuloma Annulare; Morphea; Lichen Planus

 

Last Updated: 13 Aug 2018

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Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers
 

Status: Recruiting

Condition Summary: Adenoid Cystic Carcinoma; Adnexal Carcinoma; Apocrine Carcinoma; Eccrine Porocarcinoma; Extraocular Cutaneous Sebaceous Carcinoma; Hidradenocarcinoma; Keratoacanthoma; Malignant Sweat Gland Neoplasm; Merkel Cell Carcinoma; Microcystic Adnexal Carcinoma; NK-Cell Lymphoma, Unclassifiable; Non-Melanomatous Lesion; Paget Disease; Papillary Adenocarcinoma; Primary Cutaneous Mucinous Carcinoma; Refractory Anaplastic Large Cell Lymphoma; Refractory Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Refractory Mycosis Fungoides; Refractory Primary Cutaneous T-Cell Non-Hodgkin Lymphoma; Refractory T-Cell Non-Hodgkin Lymphoma; Sezary Syndrome; Signet Ring Cell Carcinoma; Skin Basal Cell Carcinoma; Skin Basosquamous Cell Carcinoma; Skin Squamous Cell Carcinoma; Spiradenocarcinoma; Squamous Cell Carcinoma of Unknown Primary Origin; Stage III Skin Cancer; Stage IV Skin Cancer; Sweat Gland Carcinoma; Trichilemmocarcinoma; Vulvar Squamous Cell Carcinoma

 

Last Updated: 19 Nov 2018

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