Twin twin transfusion syndrome

Common Name(s)

Twin twin transfusion syndrome, Twin to Twin Transfusion Syndrome (TTTS)

Twin-to-twin transfusion syndrome is a rare condition that occurs when blood moves from one identical twin (the Òdonor twinÓ) to the other (the Òrecipient twinÓ) while in the womb. The donor twin may be born smaller, with paleness, anemia, and dehydration. The recipient twin may be born larger, with redness, too much blood, and increased blood pressure, resulting in an increased risk for heart failure. Treatment may require repeated amniocentesis during pregnancy. Fetal laser surgery may be done to interrupt the flow of blood from one twin to the other. After birth, treatment depends on the infant's specific symptoms. The donor twin may need a blood transfusion to treat anemia. The recipient twin may need to have the volume of body fluid reduced. This may involve an exchange transfusion. Medications may be given to treat heart failure in the recipient twin.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Twin twin transfusion syndrome" for support, advocacy or research.

Sidelines National Support Network

Sidelines provides support, education, advocacy and resources to women and their families experiencing a complicated high-risk pregnancy or premature birth.

Last Updated: 4 Apr 2013

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The Twin to Twin Transfusion Syndrome Foundation

The first and only nonproft organization in the world solely dedicated to providing immediate and lifesaving educational, emotional and financial support to families, medical professionals, and other caregivers before, during, and after a diagnosis of twin to twin transfusion syndrome. Dedicated to saving the babies, improving their future health and care, providing NICU, special needs and bereavement support, furthering medical research, and keeping families together the way twins are meant to be.

Last Updated: 12 Jan 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Twin twin transfusion syndrome" for support, advocacy or research.

Sidelines National Support Network

Sidelines provides support, education, advocacy and resources to women and their families experiencing a complicated high-risk pregnancy or premature birth.

http://www.sidelines.org

Last Updated: 4 Apr 2013

View Details
The Twin to Twin Transfusion Syndrome Foundation

The first and only nonproft organization in the world solely dedicated to providing immediate and lifesaving educational, emotional and financial support to families, medical professionals, and other caregivers before, during, and after a diagnosis of twin to twin transfusion syndrome. Dedicated to saving the babies, improving their future health and care, providing NICU, special needs and bereavement support, furthering medical research, and keeping families together the way twins are meant to be.

http://www.tttsfoundation.org

Last Updated: 12 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Twin twin transfusion syndrome" returned 171 free, full-text research articles on human participants. First 3 results:

Twin-twin transfusion syndrome in a monozygotic pregnancy with obvious lambda sign in first-trimester ultrasound.
 

Author(s): Susumu Murata, Mayumi Takano, Yukiko Kagawa, Michihisa Fujiwara, Masahiro Sumie, Masahiko Nakata

Journal: Taiwan J Obstet Gynecol. 2016 Dec;55(6):904-906.

 

Last Updated: 31 Dec 1969

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[Outcome of triplet pregnancies managed for twin-to-twin transfusion syndrome: A single center experience].
 

Author(s): G E Chalouhi, T Quibel, N Benzina, J-P Bernard, M Essaoui, Y Ville

Journal: J Gynecol Obstet Biol Reprod (Paris). 2016 Oct;45(8):929-935.

 

Study the outcomes of triplet pregnancies (GGG) complicated with twin-to-twin transfusion syndrome (TTTS) treated with laser fetoscopy.

Last Updated: 31 Dec 1969

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Outcome of twin-twin transfusion syndrome treated by laser therapy in Taiwan's single center: Role of Quintero staging system.
 

Author(s): Yao-Lung Chang, An-Shine Chao, Shuenn-Dyh Chang, Peter Cc Hsieh, Sheng-Yuan Su, Kuan-Ju Chen, Po-Jen Cheng, Tzu-Hao Wang

Journal: Taiwan J Obstet Gynecol. 2016 Oct;55(5):700-704.

 

To evaluate the outcome of twin-twin transfusion syndrome (TTTS) treated by fetoscopic laser therapy (FLT) stratified by Quintero staging.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Twin twin transfusion syndrome" returned 12 free, full-text review articles on human participants. First 3 results:

Twenty-Five Years of Fetoscopic Laser Coagulation in Twin-Twin Transfusion Syndrome: A Systematic Review.
 

Author(s): Joost Akkermans, Suzanne H P Peeters, Frans J Klumper, Enrico Lopriore, Johanna M Middeldorp, Dick Oepkes

Journal: Fetal. Diagn. Ther.. 2015 ;38(4):241-53.

 

The aim of this study was to assess the perinatal outcome of pregnancies with twin-twin transfusion syndrome (TTTS) treated with laser therapy over the past 25 years, and in relation to different techniques used in this time period.

Last Updated: 31 Dec 1969

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Perinatal outcome after fetoscopic laser surgery for twin-to-twin transfusion syndrome in triplet pregnancies.
 

Author(s): F D'Antonio, B Thilaganathan, J Toms, L Manzoli, A Bhide, A Papageorghiou, A Khalil

Journal: BJOG. 2016 Feb;123(3):328-36.

 

The introduction of fetoscopic laser surgery of placental anastomoses has led to a significant improvement of perinatal outcome of twin pregnancies affected by twin-to-twin-transfusion syndrome (TTTS). To quantify the perinatal outcome and neurological morbidity in triplet pregnancies ...

Last Updated: 31 Dec 1969

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Comparison of Solomon technique with selective laser ablation for twin-twin transfusion syndrome: a systematic review.
 

Author(s): R K Dhillon, S C Hillman, R Pounds, R K Morris, M D Kilby

Journal: Ultrasound Obstet Gynecol. 2015 Nov;46(5):526-33.

 

To compare the Solomon and selective techniques for fetoscopic laser ablation (FLA) for the treatment of twin-twin transfusion syndrome (TTTS) in monochorionic-diamniotic twin pregnancies.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Sequential vs. Standard Laser Treatment of Twin-twin Transfusion Syndrome
 

Status: Recruiting

Condition Summary: Twin Twin Transfusion Syndrome

 

Last Updated: 8 Mar 2017

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Last Updated: 6 Jan 2017

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Neonatal Outcome for Laser Coagulation in Twin-to-twin-transfusion Syndrome
 

Status: Recruiting

Condition Summary: TTTS

 

Last Updated: 12 May 2017

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