Typhus

Common Name(s)

Typhus

Typhus is a general term for a group of diseases passed on by lice, flea, tick, and other insect bites. Types of typhus include epidemic typhus, scrub typhus, murine typhus. Common symptoms of most typhus cases include fever, headache, muscle aches, rapid breathing, and rash. Typhus is uncommon in the United States and can be prevented by avoiding contact with rats and keeping pets treated for ticks and fleas. Usually typhus can be cured with antibiotics.

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Condition Specific Organizations

Following organizations serve the condition "Typhus" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Typhus" returned 411 free, full-text research articles on human participants. First 3 results:

Strong interferon-gamma mediated cellular immunity to scrub typhus demonstrated using a novel whole cell antigen ELISpot assay in rhesus macaques and humans.
 

Author(s): Manutsanun Sumonwiriya, Daniel H Paris, Piyanate Sunyakumthorn, Tippawan Anantatat, Kemajittra Jenjaroen, Suchintana Chumseng, Rawiwan Im-Erbsin, Ampai Tanganuchitcharnchai, Suthatip Jintaworn, Stuart D Blacksell, Fazle R Chowdhury, Barbara Kronsteiner, Prapit Teparrukkul, Robin L Burke, Eric D Lombardini, Allen L Richards, Carl J Mason, James W Jones, Nicholas P J Day, Susanna J Dunachie

Journal:

 

Scrub typhus is a febrile infection caused by the obligate intracellular bacterium Orientia tsutsugamushi, which causes significant morbidity and mortality across the Asia-Pacific region. The control of this vector-borne disease is challenging due to humans being dead-end hosts, vertical ...

Last Updated: 31 Dec 1969

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Increased level and interferon-γ production of circulating natural killer cells in patients with scrub typhus.
 

Author(s): Seung-Ji Kang, Hye-Mi Jin, Young-Nan Cho, Seong Eun Kim, Uh Jin Kim, Kyung-Hwa Park, Hee-Chang Jang, Sook-In Jung, Seung-Jung Kee, Yong-Wook Park

Journal:

 

Natural killer (NK) cells are essential immune cells against several pathogens. Not much is known regarding the roll of NK cells in Orientia tsutsugamushi infection. Thus, this study aims to determine the level, function, and clinical relevance of NK cells in patients with scrub typhus.

Last Updated: 31 Dec 1969

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Acute Encephalitis Syndrome and Scrub Typhus in India.
 

Author(s): Manoj V Murhekar

Journal: Emerging Infect. Dis.. 2017 08;23(8):1434.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Typhus" returned 22 free, full-text review articles on human participants. First 3 results:

A review of the global epidemiology of scrub typhus.
 

Author(s): Guang Xu, David H Walker, Daniel Jupiter, Peter C Melby, Christine M Arcari

Journal:

 

Scrub typhus is a serious public health problem in the Asia-Pacific area. It threatens one billion people globally, and causes illness in one million people each year. Caused by Orientia tsutsugamushi, scrub typhus can result in severe multiorgan failure with a case fatality rate ...

Last Updated: 31 Dec 1969

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Estimating the burden of scrub typhus: A systematic review.
 

Author(s): Ana Bonell, Yoel Lubell, Paul N Newton, John A Crump, Daniel H Paris

Journal:

 

Scrub typhus is a vector-borne zoonotic disease that can be life-threatening. There are no licensed vaccines, or vector control efforts in place. Despite increasing awareness in endemic regions, the public health burden and global distribution of scrub typhus remains poorly known.

Last Updated: 31 Dec 1969

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Comparative effectiveness of azithromycin for treating scrub typhus: A PRISMA-compliant systematic review and meta-analysis.
 

Author(s): Szu-Chia Lee, Yu-Jyun Cheng, Chao-Hsu Lin, Wei-Te Lei, Hung-Yang Chang, Ming-Dar Lee, Jui-Ming Liu, Ren-Jun Hsu, Nan-Chang Chiu, Hsin Chi, Chun-Chih Peng, Te-Lung Tsai, Chien-Yu Lin

Journal: Medicine (Baltimore). 2017 Sep;96(36):e7992.

 

Scrub typhus is a zoonotic disease that remains an important health threat in endemic areas. Appropriate anti-rickettsial treatment ensures a successful recovery. Doxycycline is a recommended drug, but it is contraindicated in pregnant women and young children. Azithromycin is a safer ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Scrub Typhus Antibiotic Resistance Trial
 

Status: Recruiting

Condition Summary: Scrub Typhus

 

Last Updated: 12 Dec 2017

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Scrub Typhus Pediatric Immunology Study
 

Status: Recruiting

Condition Summary: Scrub Typhus

 

Last Updated: 31 Aug 2016

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Scrub Typhus RDT Study
 

Status: Not yet recruiting

Condition Summary: The Prevalence of Scrub Typhus

 

Last Updated: 10 Nov 2017

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